Which sclerosant is not FDA approved?

The sclerosant that is not FDA approved is high volume hypertonic saline (HTS). While hypertonic saline itself is used in certain medical contexts, high volume formulations of it have not undergone the necessary FDA approval processes specific to sclerotherapy. This distinction is important in clinical practice, as the FDA approval ensures that the treatment has met safety and efficacy standards for its specific use in the context of sclerotherapy.

In practices, other sclerosants like hypertonic saline, polidocanol, and sodium tetradecyl sulfate have received FDA approval for use in treating superficial venous insufficiency through sclerotherapy. Their approval means they've been evaluated for their effectiveness and safety in treating varicose veins and similar conditions, providing healthcare professionals with a reliable option for managing such vascular issues.